The Regev lab develops experimental and computational approaches to systematically decipher the mechanisms that underlie the transcriptional regulatory circuits in organisms ranging from yeast to humans. Lab members study how these transcriptional circuits change on a variety of timescales: for example, when cells respond to changing growth conditions (within hours); when cells differentiate (within hours to days); and when species evolve (across millions of years). These studies yield detailed reconstructions and highlight key principles that govern the emergence of novel functions in gene regulation. Major areas of research include: reconstruction of the regulatory circuitry of mammalian cells, circuits controlling cell differentiation, the evolution of gene regulation, and gene regulatory networks in cancer cells. (modified from https://www.broadinstitute.org/regev-lab/areas-focus)